Even when the bag is full, it is comfortable to run with. The straps tighten the bag to your back and the foam pad keeps it stable, so there is no bounce or space when you run. The straps are also laid out perfectly not to chafe any part of your body.
The Osprey bag has been a great casual and running bag. When I use it to walk or bike, I will keep it loose and balances well on my back. What surprised me the most was how much space is in it. You can fit a pair of shoes, clothes and a bike helmet comfortably into the large pouch, while also fitting your keys, wallet, and phone into the smaller pocket on top.
I do not have to travel with a computer to work, so cannot speak to how heavy the bag might get with larger items. I also have not used the slot available to place a Camel Bak so I am unable to speak to how well it works or if condensation leaks into the bag. The only complaint I have is when the bag is full, your water bottle will not fit in the side pockets.
Otherwise, the bag has been very durable and I recommend it to anyone looking for a bag to run to work with!